Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects. The Grewia asiatica commonly known as Phalsa or Fasla is a shrub or small tree found in southern Asia. It produces purple to black color fruit when ripe. In folk medicine the edible Grewia asiatica fruit is used in a number of pathological conditions.
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Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects. The Grewia asiatica commonly known as Phalsa or Fasla is a shrub or small tree found in southern Asia. It produces purple to black color fruit when ripe. In folk medicine the edible Grewia asiatica fruit is used in a number of pathological conditions. The current study described the effects of Grewia asiatica fruit on glycemic index GI and phagocytosis in healthy non-diabetic human subjects.
The results showed that Grewia asiatica fruit has low GI value of 5. Luminol-enhanced chemiluminescence assay was carried out to determine the production of reactive oxygen species ROS in the oxidative burst activity of whole blood. ROS production was found to be significantly affected, having the The aqueous, methanolic and butanolic extracts of Grewia asiatica fruits were found to produce a stimulatory effect on ROS production however; the chloroform, hexane and ethanol-acetate extracted exerted significant inhibitory effect.
These results demonstrated that Grewia asiatica fruit has desirable effects on blood glucose metabolism manifested as low glycemic response and modulation of ROS production. PubMed Central. Khattab, Hala A. Diabetes mellitus is regarded as a serious chronic disease that carries a high risk for considerable complications. In folk medicine, the edible Grewia asiatica fruit is used in a number of pathological conditions.
This study aimed to investigate the possible curative effect of G. Furthermore, mechanism of antihyperglycemic action is investigated. The treatment also protects against STZ-induced pathological changes in the pancreas. The results of this study indicated that G.
Molecular and functional characterization of two isoforms of chalcone synthase and their expression analysis in relation to flavonoid constituents in Grewia asiatica L. Chalcone synthase constitutes a functionally diverse gene family producing wide range of flavonoids by catalyzing the initial step of the phenylpropanoid pathway.
There is a pivotal role of flavonoids in pollen function as they are imperative for pollen maturation and pollen tube growth during sexual reproduction in flowering plants. Here we focused on medicinally important fruit -bearing shrub Grewia asiatica.
It is a rich repository of flavonoids. The fruits are highly acclaimed for various putative health benefits. Despite its importance, full commercial exploitation is hampered due to two drawbacks which include short shelf life of its fruits and larger seed volume. To circumvent these constraints, seed abortion is one of the viable options. Molecular interventions tested in a number of economic crops have been to impair male reproductive function by disrupting the chalcone synthase CHS gene activity.
KX with an ORF of and bp, respectively. GaCHSs were heterologously expressed and purified in E. Functionality of CHS isoforms was also characterized via enzyme kinetic studies using five different substrates.
We observed differential substrate specificities in terms of their Km and Vmax values. Accumulation of flavonoid constituents naringenin and quercetin were also quantified and their relative concentrations corroborated well with the expression levels of GaCHSs. Further, our results demonstrate that GaCHS isoforms show differential expression patterns at different reproductive phenological stages. Transcript levels of GaCHS2 were more than its isoform GaCHS1 at the anthesis stage of flower development pointing towards its probable role in male reproductive maturity.
New triterpenes from Barringtonia asiatica. The leaves of Barringtonia asiatica afforded two new triterpenes, germanicol caffeoyl ester 1 and camelliagenone 2. It also afforded germanicol trans-coumaroyl ester 3 , germanicol cis-coumaroyl ester 4 , germanicol 5 , camelliagenin A 6 , spinasterol, sitosterol, squalene, lutein and trilinolein. Compounds 3, spinasterol and trilinolein were isolated from the fruits , while the seeds yielded spinasterol, squalene, linoleic acid and trilinolein.
Compounds exhibited antifungal activity against Candida albicans, and 5 showed antibacterial activity against Staphylococcus aureus, while 5 is active against Pseudomonas aeruginosa. Centella asiatica in cosmetology. Centella asiatica known as Gotu Kola is a medicinal plant that has been used in folk medicine for hundreds of years as well as in scientifically oriented medicine. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids.
Centella asiatica is effective in improving treatment of small wounds, hypertrophic wounds as well as burns, psoriasis and scleroderma. The mechanism of action involves promoting fibroblast proliferation and increasing the synthesis of collagen and intracellular fibronectin content and also improvement of the tensile strength of newly formed skin as well as inhibiting the inflammatory phase of hypertrophic scars and keloids.
Research results indicate that it can be used in the treatment of photoaging skin, cellulite and striae. Plantago asiatica mosaic virus — data sheet. PlAMV also naturally infects P. Updating Taenia asiatica in humans and pigs. An epidemiological study on taeniasis and cysticercosis in northern India has recently updated the epidemiology of Taenia asiatica.
Practically, all the detected cases of taeniasis were caused by T. The finding widens the geographical distribution of T. Due to the introduction of molecular techniques in Taenia diagnosis, the species is slowly showing its true distribution. A human Taenia species with cosmopolitan hosts the same as the other two Taenia species but limited to a specific geographical area and not affected by globalisation would certainly be hard to believe. Regarding cysticercosis, there is a remarkable finding concerning T.
This is the first time that the cysticercus of T. This fact is actually relevant since people are at a greater risk of becoming infected by T. The Taenia species causing Taenia saginata-like taeniasis around the world, as well as pig and human cysticercosis, should always be molecularly confirmed since T. Immunoblot Patterns of Taenia asiatica Taeniasis. Differential diagnosis of Taenia asiatica infection from other human taeniases by serology has been tested.
An enzyme-linked immunoelectrotransfer blot EITB was applied to subjected human sera and tapeworm materials. Thirty-eight proteins reactive to serum IgG were observed between and 10 kDa in adult worms, and more than 22 serum-reactive components between 97 kDa and Antigens of adult T. Antigens of adult Taenia saginata revealed , 66, , and 46 kDa immunoblot bands against T. Antigens of adult Taenia solium also revealed , , and 46 kDa bands against T. The immunoblot band of Immunoblot patterns of Taenia asiatica taeniasis.
Grewia gum as a potential aqueous film coating agent. I: Some physicochemical characteristics of fractions of grewia gum. Background: Grewia gum has received attention as a polymeric pharmaceutical excipient in the recent times, being employed as a suspending, film coating, mucoadhesive, and binding agent. The low aqueous solubility, however, has limited its characterization and application. Objective: The purpose of this study was to fractionate and evaluate some physicochemical properties of the gum.
Skeletal density, solubility, particle size, and rheological as well as thermal characteristics of the fractions were evaluated. The solubility of the gum increased up to fourfold while the viscosity decreased from to as low as70 cP at 40 rpm with some fractions. The molecular weight averages by weight and by number of the fractions were between , and , The 1H nuclear magnetic resonance NMR spectra showed broad peaks. Conclusion: The fractionation improved solubility and facilitated further investigations on its characteristics that may have implication on its processing, application, and optimization as a potential pharmaceutical excipient.
Molecular Approaches to Taenia asiatica. Taenia solium, T. Taeniases remain an important public health concerns in the world. The mitochondrial gene sequence is believed to be a very useful molecular marker for not only studying evolutionary relationships among distantly related taxa, but also for investigating the phylo-biogeography of closely related species.
The complete sequence of the human Taenia tapeworms mitochondrial genomes were determined, and its organization and structure were compared to other human-tropic Taenia tapeworms for which complete mitochondrial sequence data were available.
The multiplex PCR assay with the TaF, TsF, TsoF, and Rev primers will be useful for differential diagnosis, molecular characterization, and epidemiological surveys of human Taenia tapeworms. Molecular approaches to Taenia asiatica. Historical overview of Taenia asiatica in Taiwan.
An overview of the epidemiological, biological, and clinical studies of Taenia and taeniasis in Taiwan for the past century is presented. The phenomenal observations that led to the discovery of Taenia asiatica as a new species, which differ from Taenia solium and Taenia saginata, are described.
Parasitological surveys of the aborigines in Taiwan revealed a high prevalence of taeniasis, which might be due to the culture of eating raw liver of hunted wild boars. Chemotherapeutic deworming trials involving many patients with taeniasis were discussed. Praziquantel was found to be very effective, but sometimes complete worms could not be recovered from the feces after treatment, probably due to the dissolution of the proglottids.
Atabrine, despite some side effects, can still be used, in properly controlled dosages, as the drug of choice for human T. Research results on the infection of T. Since the pig serve as the natural intermediate host of T. Historical Overview of Taenia asiatica in Taiwan. In a botanical sense, fruits are the developed part of the seed-containing ovary. Evolutionarily speaking, plants have developed fruit with the goal of attracting insects, birds, reptiles and mammals to spread the seeds.
Fruit can be dry such as the pod of a pea, or fleshy such as a peach. As humans Therapeutic effect of praziquantel against Taeniasis asiatica. Eight Japanese adult patients infected with Taenia asiatica were treated with a single mg dose of praziquantel.
Grewia asiatica L.
Click on images to enlarge. Native to the Indian sub-continent i. Cambodia, Laos and Thailand. This species has occasionally been cultivated in the warmer parts of Australia. It was first reported to be naturalised not far from the Darwin Botanic Gardens, where it was beng cultivated. This species is becoming widely naturalised in northern Australia. It was first recorded in Darwin, and has since become relatively widespread in the northern parts of the Northern Territory.
Antioxidant, Antimicrobial Activity and Medicinal Properties of Grewia Asiatica L
Grewia asiatica L. Fruits are a rich source of nutrients such as proteins, amino acids, vitamins, and minerals and contain various bioactive compounds, like anthocyanins, tannins, phenolics and flavonoids. Different parts of this plant possess different pharmacological properties. Leaves have antimicrobial, anticancer, antiplatelet and antiemetic activities; fruit possess anticancer, antioxidant, radioprotective and antihyperglycemic properties; while stem bark possesses analgesic and anti-inflammatory activities.
Weeds of Australia - Biosecurity Queensland Edition Fact Sheet
Since ancient time, India is a well known subcontinent for medicinal plants where diversity of plants is known for the treatment of many human disorders. Grewia asiatica is a dicot shrub belonging to the Grewioideae family and well known for its medicinally important fruit commonly called Falsa. Fruits of G. Recent advancement of Falsa researches concluded its antimicrobial and anti-diabetic activity. Since ancient time medicinal plants are traditionally used for the treatment of different diseases G. Now a days, G. Different pharmacological investigations reveal the presence of phenols, saponnins, flavonoids and tannins compound in the fruits.