It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes. Women who were in the 24th to 31st week of gestation and who met the criteria for mild gestational diabetes mellitus i. The primary outcome was a composite of stillbirth or perinatal death and neonatal complications, including hyperbilirubinemia, hypoglycemia, hyperinsulinemia, and birth trauma. A total of women were randomly assigned to a study group — to the treatment group and to the control group. We observed no significant difference between groups in the frequency of the composite outcome

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Background: We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications.

Methods: We randomly assigned women between 24 and 34 weeks' gestation who had gestational diabetes to receive dietary advice, blood glucose monitoring, and insulin therapy as needed the intervention group or routine care.

Primary outcomes included serious perinatal complications defined as death, shoulder dystocia, bone fracture, and nerve palsy , admission to the neonatal nursery, jaundice requiring phototherapy, induction of labor, cesarean birth, and maternal anxiety, depression, and health status. Results: The rate of serious perinatal complications was significantly lower among the infants of the women in the intervention group than among the infants of the women in the routine-care group 1 percent vs.

However, more infants of women in the intervention group were admitted to the neonatal nursery 71 percent vs. Women in the intervention group had a higher rate of induction of labor than the women in the routine-care group 39 percent vs.

At three months post partum, data on the women's mood and quality of life, available for women, revealed lower rates of depression and higher scores, consistent with improved health status, in the intervention group. Conclusions: Treatment of gestational diabetes reduces serious perinatal morbidity and may also improve the woman's health-related quality of life. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

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Full-text links Cite Favorites. Abstract Background: We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications.

Comment in Gestational diabetes mellitus -- time to treat. Greene MF, et al. N Engl J Med. Epub Jun PMID: No abstract available. Treatment of gestational diabetes mellitus. Elchalal U, Brzezinski A. Elchalal U, et al. Richard T, et al.

Screening and active management reduced perinatal complications more than routine care in gestational diabetes. Ray JG. ACP J Club. Similar articles Costs and consequences of treatment for mild gestational diabetes mellitus - evaluation from the ACHOIS randomised trial. Moss JR, et al. BMC Pregnancy Childbirth. Clinical Trial. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy.

A comparison of glyburide and insulin in women with gestational diabetes mellitus. Langer O, et al. Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes.

Nicholson WK, et al. Ned Tijdschr Geneeskd. PMID: Review. Show more similar articles See all similar articles. Clarke E, et al. J Pregnancy. Determinants of the persistency of macrosomia and shoulder dystocia despite treatment of gestational diabetes mellitus.

Development and validation of an early pregnancy risk score for the prediction of gestational diabetes mellitus in Chinese pregnant women. Gao S, et al. Wani K, et al. Front Endocrinol Lausanne. Pregnancy outcomes according to the definition of gestational diabetes. Koivunen S, et al. PLoS One. Show more "Cited by" articles See all "Cited by" articles. Publication types Clinical Trial Actions. Multicenter Study Actions. Randomized Controlled Trial Actions. Research Support, Non-U.

Gov't Actions. MeSH terms Adult Actions. Birth Weight Actions. Female Actions. Glucose Tolerance Test Actions. Humans Actions.

Infant Mortality Actions. Infant, Newborn Actions. Substances Blood Glucose Actions. Hypoglycemic Agents Actions. Insulin Actions. Full-text links [x] Atypon. Copy Download.


A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes

Metrics details. It is still uncertain whether there are benefits of similar treatment for women with borderline gestational diabetes. This trial aims to assess whether dietary and lifestyle advice and treatment given to pregnant women who screen for borderline gestational diabetes reduces neonatal complications and maternal morbidities. A conclusive trial outcome will provide reliable evidence of relevance for the care of women with borderline glucose intolerance in pregnancy and their infants. Peer Review reports. The prevalence of gestational diabetes mellitus GDM is rising worldwide [ 1 , 2 ], with recent Australian estimates indicating that between 5.


Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes


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